This second issue of 2016 includes three articles related to Engineering, and Society and Economics. Related research faces challenges such as understanding the physiological mechanisms of prosthetic vision, with the purpose of restoring vision to the blind through the development of a visual neuroprosthesis. In this direction, the first article presents an in vivo electrophysiological investigations on new stimulation paradigms that can potentially lead to improved visual perception. This paper describes a multi-viewpoint architecture of an experimental setup for the study of electrically evoked potentials in a retinal neuroprosthesis. The challenge faced by the second study presented is to ensure that voters with disabilities could vote independently. The focus of this research is to examine the viability and usability of a particular voting system, Interactive Voice Response (IVR), as an accessible voting platform for visually impaired voters. Latest challenge addresses difficulties faced by people with disability when accessing to Massive Open Online Courses (MOOCs). This revolutionary computer and mobile-based educational scenario allow students to learn at their own time, place and pace, improving, consequently, their level of employability and social inclusion. The third paper describes the need for designing an information model and related specifications to support a new strategy for delivering accessible MOOC. This approach takes into account preferences and context of use, resulting in as user profile’s design based on standard metadata schemas regarding the achievement of accessibility from content to user preferences.